"Apply lotion with SPF to protect skin from the sun," says Neal Schultz, MD , founder of DermTV.com. Stash a lotion—like Borghese Radiante Brightening Hand Creme SPF 30 ($15; at CVS), which contains soothing aloe extracts—in your bag for touchups.
"Three times a week at bedtime, pamper your hands," says Dr. Schultz, who recommends this three-step process:
Step 1: Exfoliate. Use a salt-based scrub like Yes to Carrots Feel the C Pampering Hand & Nail Spa ($11.38; ) to remove dull skin.
Step 2: Spot-treat. What works for your face will work for your hands too. Dab on a facial brightening cream to fade dark spots. We love Kiehl's Photo-Age Corrector High-Potent Spot Treatment ($49; ).
Step 3: Moisturize. Apply a lotion rich in vitamins A, C and E, such as Peter Lamas Products Spa Sensuals Hand Cream ($18; ) to restore and nourish skin overnight.
Products photos by Todd Huffman.